March 2022 – February 2023

Where publications are open access direct links have been provided in the citations.

Adolescent & other research

“We Should Be Taught Self-Respect, Self-Confidence and Self-Love”: Youth Perspectives of Adult Influences on Their Sexuality and Relationships Among South African Adolescents Living With HIV

Bergam S, Kuo C, Atujuna M, Pellowski JA, Mtukushe B, Ndevu-Qwabe N, Matiwane M, Rencken CA, Belsky M, Hoare J, Bekker LG, Harrison AD.

Published in Frontiers in Reproductive Health on July 12, 2022. DOI: 10.3389/frph.2022.913170. PMID: 36303635

Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis

Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration, Jesson J, Crichton S, Quartagno M, Yotebieng M, Abrams EJ, Chokephaibulkit K, Le Coeur S, Aké-Assi MH, Patel K, Pinto J, Paul M, Vreeman R, Davies MA, Ben-Farhat J, Van Dyke R, Judd A, Mofenson L, Vicari M, Seage G 3rd, Bekker LG, Essajee S, Gibb D, Penazzato M, Collins IJ, Wools-Kaloustian K, Slogrove A, Powis K, Williams P, Matshaba M, Thahane L, Nyasulu P, Lukhele B, Mwita L, Kekitiinwa-Rukyalekere A, Wanless S, Goetghebuer T, Thorne C, Warszawski J, Galli L, van Rossum AMC, Giaquinto C, Marczynska M, Marques L, Prata F, Ene L, Okhonskaya L, Navarro M, Frick A, Naver L, Kahlert C, Volokha A, Chappell E, Pape JW, Rouzier V, Marcelin A, Succi R, Sohn AH, Kariminia A, Edmonds A, Lelo P, Lyamuya R, Ogalo EA, Odhiambo FA, Haas AD, Bolton C, Muhairwe J, Tweya H, Sylla M, D’Almeida M, Renner L, Abzug MJ, Oleske J, Purswani M, Teasdale C, Nuwagaba-Biribonwoha H, Goodall R, Leroy V

Published in Journal of the International AIDS Society in March 2022. DOI: 10.1002/jia2.25871. PMID: 35255197

Building capacity to facilitate policy implementation: A short course in adolescent and youth health in South Africa

Ferguson BJ, Ahmed N, Motshwane FMM, Pleaner M, Toska E, Weiss HA, Bekker LG

Published in Journal of Public Health in Africa in May 2022. DOI: 10.4081/jphia.2022.1855. PMID: 35720793

The question of the question: impactful implementation science to address the HIV epidemic

Geng EH, Nash D, Phanuphak N, Green K, Solomon S, Grimsrud A, Sohn AH, Mayer KH, Bärnighausen T, Bekker LG

Published in Journal of the International AIDS Society in April 2022. DOI: 10.1002/jia2.25898. PMID: 35384312

Multilevel correlates of abdominal obesity in adolescents and youth living with HIV in peri-urban Cape Town, South Africa

Kamkuemah M, Gausi B, Oni T, Middelkoop K

Published in PLoS One in January 2023. DOI: 10.1371/journal.pone.0266637.

Ethically acceptable consent approaches to adolescent research in South Africa

Loveday M, Goga A, Dhai A, Labuschaigne M, Roussouw T, Burgess T, Strode A, Wallace M, Blockman M, Daniels B, Spooner E, Bekker LG

Published in South African Journal of HIV Medicine in September 2022. DOI: 10.4102/sajhivmed.v23i1.1385. PMID: 36299555

HIV Prevention

“We Should Be Taught Self-Respect, Self-Confidence and Self-Love”: Youth Perspectives of Adult Influences on Their Sexuality and Relationships Among South African Adolescents Living With HIV

Bergam S, Kuo C, Atujuna M, Pellowski JA, Mtukushe B, Ndevu-Qwabe N, Matiwane M, Rencken CA, Belsky M, Hoare J, Bekker LG, Harrison AD.

Published in Frontiers in Reproductive Health on July 12, 2022. DOI: 10.3389/frph.2022.913170. PMID: 36303635

Oral pre-exposure prophylaxis uptake, adherence, and adverse events among South African men who have sex with men and transgender women

Bekker LG, Giovenco D, Baral S, Dominguez K, Valencia R, Sanchez T, McNaghten AD, Zahn R, Yah CS, Sokhela Z, Kaplan R, Phaswana-Mafuya RN, Beyrer C, Sullivan PS

Published in South African Journal of HIV Medicine on November 8, 2022. DOI: 10.4102/sajhivmed.v23i1.1405. PMID: 36479416

Bekker et al., 2022

Long-acting agents for HIV treatment and prevention

Bekker LG

Published in Nature Medicine in August 2022. DOI: 10.1038/s41591-022-01917-w. PMID: 35869309

HIV-related stigma, disclosure and social support: experiences among young pregnant and postpartum women living with HIV in South Africa

Brittain K, Gomba Y, Noholoza S, Pellowski J, Mellins CA, Bekker LG, Kagee A, Remien RH, Abrams EJ, Myer L

Published in AIDS Care on September 14, 2022. DOI: 10.1080/09540121.2022.2121957. PMID: 36102063

Assessing the association of stigma and HIV service and prevention uptake among men who have sex with men and transgender women in South Africa

Brown CA, Siegler AJ, Zahn RJ, Valencia RK, Sanchez T, Kramer MR, Phaswana-Mafuya NR, Stephenson R, Bekker LG, Baral SD, Sullivan PS

Published in AIDS Care on February 8, 2023. DOI: 10.1080/09540121.2023.2175770. PMID: 36755403

PrEP use and HIV seroconversion rates in adolescent girls and young women from Kenya and South Africa: the POWER demonstration project

Celum CL, Bukusi EA, Bekker LG, Delany-Moretlwe S, Kidoguchi L, Omollo V, Rousseau E, Travill D, Morton JF, Mogaka F, O’Malley G, Barnabee G, van der Straten A, Donnell D, Parikh UM, Kudrick L, Anderson PL, Haberer JE, Wu L, Heffron R, Johnson R, Morrison S, Baeten JM; POWER Study Team

Published in Journal of the International AIDS Society in July 2022. DOI: 10.1002/jia2.25962. PMID: 35822945

“I know why I am taking this pill”: Young women navigation of disclosure and support for PrEP uptake and adherence in Eastern Cape Province, South Africa

Daniels J, De Vos L, Bezuidenhout D, Atujuna M, Celum C, Hosek S, Bekker LG, Medina-Marino A

Published in PLOS ONE on January 20, 2023. DOI: 10.1371/journal.pgph.0000636. PMID: 36962727

Factors that influence adolescent girls and young women's re‐initiation or complete discontinuation from daily oral PrEP use: a qualitative study from Eastern Cape Province, South Africa

de Vos L, Mudzingwa EK, Atujuna M, Fynn L, Mugore M, Hosek S, Celum C, Bekker LG, Daniels J, Medina-Marino A

Published in AIDS and Behavior on June 2, 2022. DOI: 10.1007/s10461-022-03702-9. PMID: 35653046

A multi‐country cross‐sectional study to assess predictors of daily versus on‐demand oral pre‐exposure prophylaxis in youth from South Africa, Uganda and Zimbabwe

HIV RNA Screening Reduces Integrase Strand Transfer Inhibitor Resistance Risk in Persons Receiving Long-Acting Cabotegravir for HIV Prevention

Eshleman SH, Fogel JM, Halvas EK, Piwowar-Manning E, Marzinke MA, Kofron R, Wang Z, Mellors J, McCauley M, Rinehart AR, St Clair M, Adeyeye A, Hinojosa JC, Cabello R, Middelkoop K, Hanscom B, Cohen MS, Grinsztejn B, Landovitz RJ

Published in The Journal of Infectious Diseases in 2022. Volume: 226, Issue: 12, Pages: 2170-2180.

Intimate partner violence and oral HIV pre-exposure prophylaxis adherence among young African women

Giovenco D, Pettifor A, Powers KA, Hightow-Weidman L, Pence BW, Celum C, Delany-Moretlwe S, Hosek S, Donnell D, Anderson PL, Mgodi N, Bekker LG

AIDS (2022) Jul 1;36(8):1151-1159. DOI: 10.1097/QAD.0000000000003216. PMID: 35579012

Medina-Marino et al, 2022

Understanding Oral Prep Interest Among South African Adolescents: The Role of Perceived Parental Support and PrEP Stigma

Giovenco D, Pettifor A, Bekker LG, Filiatreau LM, Liu T, Akande M, Gill K, Atujuna M, Stein DJ, Kuo C

AIDS Behav. (2023), Nov 16. DOI: 10.1007/s10461-022-03924-x. PMID: 36383273

Adherence challenges with daily oral pre‐exposure prophylaxis during pregnancy and the postpartum period in South African women: a cohort study

Joseph Davey D, Nyemba DC, Castillo-Mancilla J, Wiesner L, Norman J, Mvududu R, Mashele N, Johnson LF, Bekker LG, Gorbach P, Coates TJ, Myer L

J Int AIDS Soc. (2022) Dec;25(12):e26044. DOI: 10.1002/jia2.26044. PMID: 36480171

Use of Varied Screening Risk Criteria and HIV Incidence in Phase 1 and 2 HIV Vaccine Trials in South Africa

Laher F, Otwombe K, Mokwena O, Bekker LG, Allen M

AIDS Behav. 2022 Oct 26. DOI: 10.1007/s10461-022-03867-3. PMID: 36287343.

Acceptability and feasibility of leveraging community‐based HIV counselling and testing platforms for same‐day oral PrEP initiation among adolescent girls and young women in Eastern Cape, South Africa

Medina-Marino A, Bezuidenhout D, Ngwepe P, Bezuidenhout C, Facente SN, Mabandla S, Hosek S, Little F, Celum CL, Bekker LG

J Int AIDS Soc. (2022 ) Jul;25(7):e25968. DOI: 10.1002/jia2.25968. PMID: 35872602

Sexual Risk among Pregnant Women at Risk of HIV Infection in Cape Town, South Africa: What Does Alcohol Have to Do with It?

Miller AP, Shoptaw S, Mvududu R, Mashele N, Coates TJ, Bekker LG, Essack Z, Groenewald C, Petersen Z, Gorbach PM, Myer L, Joseph Davey DL

AIDS Behav. (2022) Jun 23. doi: 10.1007/s10461-022-03742-1. PMID: 35737280

South Africa PrEP provision guidelines: graphical depiction of tests required at initiation and follow‐up visits Mudimu et al., 2022

Analysis of the HIV Vaccine Trials Network 702 Phase 2b–3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T-Cell Correlates of HIV-1 Acquisition Risk

Moodie Z, Dintwe O, Sawant S, Grove D, Huang Y, Janes H, Heptinstall J, Omar FL, Cohen K, De Rosa SC, Zhang L, Yates NL, Sarzotti-Kelsoe M, Seaton KE, Laher F, Bekker LG, Malahleha M, Innes C, Kassim S, Naicker N, Govender V, Sebe M, Singh N, Kotze P, Lazarus E, Nchabeleng M, Ward AM, Brumskine W, Dubula T, Randhawa AK, Grunenberg N, Hural J, Kee JJ, Benkeser D, Jin Y, Carpp LN, Allen M, D’Souza P, Tartaglia J, DiazGranados CA, Koutsoukos M, Gilbert PB, Kublin JG, Corey L, Andersen-Nissen E, Gray GE, Tomaras GD, McElrath MJ

J Infect Dis (2022) Aug 24;226(2):246-257. DOI: 10.1093/infdis/jiac260. PMID: 35758878

Incremental costs of integrated PrEP provision and effective use counselling in community‐based platforms for adolescent girls and young women in South Africa: an observational study

Mudimu E, Sardinia J, Momin S, Medina-Marino A, Bezuidenhout C, Bekker L-G, Barnabas RV, Peebles K

Journal of the International AIDS Society (2022) 25(2), e25875. DOI: 10.1002/jia2.25875.

Non-ART trained health-care workers needed to prescribe PrEP in South Africa

Nelson A, Gray A, Bekker LG, Grimsrud A, Wilkinson LS, Davey DJ

Lancet HIV (2022) Jul;9(7):e458. DOI: 10.1016/S2352-3018(22)00139-4. PMID: 35777407

Interrogating the promise of long-acting HIV pre-exposure prophylaxis

Pike C, Bekker LG

Trends Mol Med. 2023 Feb;29(2):93-98. DOI: 10.1016/j.molmed.2022.11.003. PMID: 36435632

Infusion reactions after receiving the broadly neutralizing antibody VRC01 or placebo to reduce HIV-1 acquisition: Results from the phase 2b Antibody Mediated Prevention (AMP) randomized trials

Takuva S, Karuna ST, Juraska M, Rudnicki E, Edupuganti S, Anderson M, De La Grecca R, Gaudinski MR, Sehurutshi A, Orrell C, Naidoo L, Valencia J, Villela LM, Walsh SR, Andrew P, Karg C, Randhawa A, Hural J, Gomez Lorenzo MM, Burns DN, Ledgerwood J, Mascola JR, Cohen M, Corey L, Mngadi K, Mgodi NM

AIDS (2022). 89(4), pp. 405-413. DOI: 10.1086/1185467.

The overlap between PTSD, depression and anxiety in CHAPS survey participants -- Webb et al., 2022

Alignment of PrEP adherence with periods of HIV risk among adolescent girls and young women in South Africa and Zimbabwe: A secondary analysis from the HPTN 082 randomized controlled trial

Velloza J, Donnell D, Hosek S, Anderson PL, Chirenje ZM, Mgodi N, Bekker LG, Marzinke MA, Delany-Moretlwe S, Celum C

Lancet HIV (2022) Sep 7:S2352-3018(22)00195-3. DOI: 10.1016/S2352-3018(22)00195-3. PMID: 36087612

Symptoms of post-traumatic stress and associations with sexual behaviour and PrEP preferences among young people in South Africa, Uganda and Zimbabwe

Webb EL, Dietrich JJ, Ssemata AS, Nematadzira TG, Hornschuh S, Kakande A, Tshabalala G, Muhumuza R, Mutonyi G, Atujuna M, Bere T, Bekker LG, Abas MA, Weiss HA, Seeley J, Stranix-Chibanda L, Fox J; CHAPS Study Team

BMC Infect Dis. (2022) May 16;22(1):466. DOI: 10.1186/s12879-022-07430-2. PMID: 35578175

HIV Treatment

Distribution of the intra-PBMC DRV trough concentrations (left) and intra-PBMC/plasma concentration ratios (right) in each treatment period. Whiskers represents the first and fourth quartile, respectively; circles represent mild outliers (>2 standard deviations), and asterisks represent extreme outliers (>3 standard deviations). De Nicolò et al., 2022

Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa

Belus JM, Joska JA, Bronsteyn Y, Rose AL, Andersen LS, Regenauer KS, Myers B, Hahn JA, Orrell C, Safren SA, Magidson JF

AIDS and Behavior (2022). 26 (11), pp. 3630-3641. DOI: 10.1007/s10461-022-04119-1.

High residual inflammation despite HIV viral suppression: Lessons learned from real-time adherence monitoring among people with HIV in Africa

Castillo-Mancilla JR, Musinguzi N, Asiimwe S, Siedner MJ, Orrell C, Bangsberg DR, Haberer JE

HIV Med. (2022) May;23(5):465-473. DOI: 10.1111/hiv.13278. PMID: 34704355

The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

De Nicolò A, Calcagno A, Motta I, De Vivo E, D’Avolio A, Perri GD, Wiesner L, Ebrahim I-E, Maartens G, Orrell C, McIlleron H

Antimicrobial Agents and Chemotherapy. (2022) 21;66(6):e0013622. DOI: 10.1128/aac.00136-22.

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

Huettner I, Krumm SA, Serna S, Brzezicka K, Monaco S, Walpole S, van Diepen A, Allan F, Hicks T, Kimuda S, Emery AM; IAVI Protocol C Investigators & The IAVI African HIV Research Network, Landais E, Hokke CH, Angulo J, Reichardt N, Doores KJ

Cell Rep. (2022) Mar 29;38(13):110611. DOI: 10.1016/j.celrep.2022.110611. PMID: 35354052

Figure 1. (A) Participant responses to the question, “Can you tell me the reasons why people are overweight or obese?” (B) Participant responses to the question, “What are the health problems that occur when a person is overweight or obese?” Hyle et al., 2023

Diet, physical activity, and obesity among ART-experienced people with HIV in South Africa

Hyle EP, Martey EB, Bekker LG, Xu A, Parker RA, Walensky RP, Middelkoop K

AIDS Care. 2023 Jan;35(1):71-77. DOI: 10.1080/09540121.2021.2012556.

Tenofovir Diphosphate in Dried Blood Spots in pregnant and postpartum women with HIV in Kenya: a novel approach to measuring peripartum adherence

Jennings L, Robbins RN, Nguyen N, Ferraris C, Leu C-S, Dolezal C, Hsiao N, Mgbako O, Joska J, Castillo- Mancilla J-R, Myer L, Anderson PL, Remiem RH, Orrell C, for the ADD-ART team

AIDS (2022) 36(7), pp. 933-940. DOI: 10.1097/QAD.0000000000003185.

Figure 1. Boxplots of adherence measures by study visit. The boxplot compares virologic outcomes (boxes) by adherence measures (vertical axis) for the 6 months, 12 months, and combined analyses in percentage (horizontal axis). Tyagi et al, 2022

Determinants and reasons for switching anti-retroviral regimen among HIV-infected youth in a large township of South Africa (2002–2019)

Kabarambi A, Balinda S, Abaasa A, Cogill D, Orrell C

AIDS Res Ther. (2022) Jun 28;19(1):32. DOI: 10.1186/s12981-022-00453-4. PMID: 35765006; PMCID: PMC9237968.

HIV Incidence (cases per 1,000 PYs) by country Rosenberg et al., 2023

Measuring patient engagement with HIV care in sub‐Saharan Africa: a scoping study

Keene CM, Ragunathan A, Euvrard J, English M, McKnight J, Orrell C

J Int AIDS Soc. (2022) Oct;25(10):e26025. DOI: 10.1002/jia2.26025. PMID: 36285618

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study

Malaba TR, Nakatudde I, Kintu K, Colbers A, Chen T, Reynolds H, Read L, Read J, Stemmet L-A, Mrubata M, Byrne K, Seden K, Twimukye A, Theunissen H, Hodel EM, Chiong J, Hu N-C, Burger D, Wang D, Byamugisha J, Alhassan Y, Bokako S, Waitt C, Taegtmeyer M, Orrell C, Lamorde M, Myer L, Khoo S, Boffito M, Clayden P, Peto T, Pozniak A, Taylor G, Kambugu A, Ayabo T, Kitaka SB, Byakika-Kibwika P, Kiiza D, Kyohairwe I, Laker E, Luswata A, Magoola J, Mayanja H, Najujuma FV, Nakijoba R, Namuddu D, Namuli T, Ntuyo P, Onzia A, Sempijja E, Tabwenda J, William B, Abrahams N, Magano P, Delport C, Hlwaya L, Mehta U, Molitsane D, Odayar J, Tambula S, Tyam M, Venfolo O, Allerton J, Nkonyana T, Mqaba S, Else L, Potter S, Neary A

The Lancet HIV (2022). 9 (8), pp. e534-e543. DOI: 10.1016/S2352-3018(22)00173-4.

Does Type of Social Support Influence Medication Adherence Among South African Adolescents Living With HIV? A Quantitative Analysis of Pilot Data

Malo VF, Ritchwood TD, Relf MV, Bekker L-G

Journal of the Association of Nurses in AIDS Care (2022). 33 (4), pp. 492- 498. DOI: 10.1097/jnc.0000000000000325.

Use of Tenofovir Diphosphate Levels to Predict Viremia During the Postpartum Period in Women Living With Human Immunodeficiency Virus (HIV): A Nested Case-Control Study

Odayar J, Orrell C, Phillips TK, Hu NC, Kabanda S, Malaba TR, Allerton J, Wiesner L, Hsiao NY, Castillo-Mancilla J, Lesosky M, Myer L

Clinical Infectious Diseases: an official publication of the Infectious Diseases Society of America (2022). 75 (5), pp. 761-767. DOI: 10.1093/cid/ciab1068.

Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size

Rasmussen TA, Ahuja SK, Kuwanda L, Vjecha MJ, Hudson F, Lal L, Rhodes A, Chang J, Palmer S, Auberson-Munderi P, Mugerwa H, Wood R, Badal-Faesen S, Pillay S, Mngqibisa R, LaRosa A, Hildago J, Petoumenos K, Chiu C, Lutaakome J, Kitonsa J, Kabaswaga E, Pala P, Ganoza C, Fisher K, Chang C, Lewin SR, Wright EJ

Clinical Infectious Diseases: an official publication of the Infectious Diseases Society of America (2022). 75 (10), pp. 1781-1791. DOI: 10.1093/cid/ciab407.

Adult HIV-1 incidence across 15 high-burden countries in sub-Saharan Africa from 2015-2019: Pooled nationally representative estimates

Rosenberg NE, Shook-Sa BE, Liu M, Stranix-Chibanda L, Yotebieng M, Sam-Agudu NA, Hudgens MG, Phiri SJ, Mutale W, Bekker LG, Moyo S, Zuma K, Charurat ME, Justman J, Chi BH

Lancet HIV (2023) Jan 23:S2352-3018(22)00328-9. DOI: 10.1016/S2352-3018(22)00328-9.

Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case–control study from Uganda and South Africa

Tyagi A, Tong Y, Rabideau DJ, Reynolds Z, De Oliveira T, Lessells R, Amanyire G, Orrell C, Asiimwe S, Chimukangara B, Giandhari J, Pillay S, Haberer JE, Siedner MJ

Antiviral Therapy (2022) 27(5):13596535221114822. DOI: 10.1177/13596535221114822.

Urine tenofovir monitoring predicts HIV viremia in patients treated with high genetic barrier regimens

van Zyl G, Jennings L, Kellermann T, Nkantsu Z, Cogill D, van Schalkwyk M, Spinelli M, Decloedt E, Orrell C, Gandhi M

AIDS (2022) Nov 15;36(14):2057-2062. DOI: 10.1097/QAD.0000000000003354.

Interventions addressing the adolescent HIV continuum of care in South Africa: a systematic review and modified Delphi analysis

Zanoni B, Archary M, Sibaya T, Ramos T, Donenberg G, Shahmanesh M, Celum C, Pettifor A, Bekker LG, Haberer J

BMJ Open (2022) Apr 29;12(4):e057797. DOI: 10.1136/bmjopen-2021-057797. PMID: 35487726


Cumulative incidence of primary COVID-19 outcomes in vaccinated and unvaccinated insured individuals (schemes A and B) by time since vaccination or matching (A) COVID-19-related hospital admissions. (B) COVID-19-related hospital admissions requiring critical or intensive care. (C) COVID-19-related deaths. Solid lines show the cumulative incidence, with shaded areas showing 95% CIs. Goga et al., 2022

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study

Bekker LG, Garrett N, Goga A, Fairall L, Reddy T, Yende-Zuma N, Kassanjee R, Collie S, Sanne I, Boulle A, Seocharan I, Engelbrecht I, Davies MA, Champion J, Chen T, Bennett S, Mametja S, Semenya M, Moultrie H, de Oliveira T, Lessells RJ, Cohen C, Jassat W, Groome M, Von Gottberg A, Le Roux E, Khuto K, Barouch D, Mahomed H, Wolmarans M, Rousseau P, Bradshaw D, Mulder M, Opie J, Louw V, Jacobson B, Rowji P, Peter JG, Takalani A, Odhiambo J, Mayat F, Takuva S, Corey L, Gray GE; Sisonke Protocol Team; Sisonke Study Team

Lancet (2022) Mar 19;399(10330):1141-1153. DOI: 10.1016/S0140-6736(22)00007-1. PMID: 35305740

Novavax NVX-COV2373 triggers neutralization of Omicron sub-lineages

Bhiman JN, Richardson SI, Lambson BE, Kgagudi P, Mzindle N, Kaldine H, Crowther C, Gray G, Bekker LG; Novavax trial clinical lead author group; Shinde V, Bennett C, Glenn GM, Madhi SA, Moore PL

Sci Rep. (2023) Jan 21;13(1):1222. DOI: 10.1038/s41598-023-27698-x. PMID: 36681693

DNA vaccines join the fight against COVID-19

Blakney AK, Bekker LG

Lancet (2022) Apr 2;399(10332):1281-1282. DOI: 10.1016/S0140-6736(22)00524-4. PMID: 35366995

Effectiveness and Durability of the BNT162b2 Vaccine against Omicron Sublineages in South Africa

Collie S, Nayager J, Bamford L, Bekker LG, Zylstra M, Gray G

N Engl J Med. (2022) Sep 14. DOI: 10.1056/NEJMc2210093. PMID: 36103455

Graphical Abstract -- Keeton et al., 2023

Effectiveness and Durability of the BNT162b2 Vaccine against Omicron Sublineages in South Africa

Collie S, Nayager J, Bamford L, Bekker LG, Zylstra M, Gray G

N Engl J Med. (2022) Sep 14. DOI: 10.1056/NEJMc2210093. PMID: 36103455

High Asymptomatic Carriage With the Omicron Variant in South Africa

Garrett N, Tapley A, Andriesen J, Seocharan I, Fisher LH, Bunts L, Espy N, Wallis CL, Randhawa AK, Miner MD, Ketter N, Yacovone M, Goga A, Huang Y, Hural J, Kotze P, Bekker LG, Gray GE, Corey L; Ubuntu Study Team

Clin Infect Dis. (2022) Mar 30:ciac237. DOI: 10.1093/cid/ciac237. PMID: 35353885

Breakthrough SARS-CoV-2 infections during periods of delta and omicron predominance, South Africa

Goga A, Bekker LG, Garrett N, Reddy T, Yende-Zuma N, Fairall L, Moultrie H, Takalani A, Trivella V, Faesen M, Bailey V, Seocharan I, Gray GE; Sisonke study team

Lancet (2022) Jul 23;400(10348):269-271. DOI: 10.1016/S0140-6736(22)01190-4. PMID: 35809579

Effectiveness of Ad26.COV2.S and BNT162b2 Vaccines against Omicron Variant in South Africa

Gray G, Collie S, Goga A, Garrett N, Champion J, Seocharan I, Bamford L, Moultrie H, Bekker LG

N Engl J Med. (2022) Jun 9;386(23):2243-2245. DOI: 10.1056/NEJMc2202061. PMID: 35507482

View of Heterologous vaccination of BNT162b2 in Ad26.COV2.S-vaccinated healthcare workers elicits long-term humoral immune response

Jacobson B, Khan A, Shulman AH, Segal B, Mayne E, Bekker L-G, Sanne I, Gray G

South African Medical Journal (2022) 112(10), pp. 828-837. DOI: 10.7196/SAMJ.2022.v112i10.16749

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Keeton R, Tincho MB, Ngomti A, Baguma R, Benede N, Suzuki A, Khan K, Cele S, Bernstein M, Karim F, Madzorera SV, Moyo-Gwete T, Mennen M, Skelem S, Adriaanse M, Mutithu D, Aremu O, Stek C, du Bruyn E, Van Der Mescht MA, de Beer Z, de Villiers TR, Bodenstein A, van den Berg G, Mendes A, Strydom A, Venter M, Giandhari J, Naidoo Y, Pillay S, Tegally H, Grifoni A, Weiskopf D, Sette A, Wilkinson RJ, de Oliveira T, Bekker LG, Gray G, Ueckermann V, Rossouw T, Boswell MT, Bhiman JN, Moore PL, Sigal A, Ntusi NAB, Burgers WA, Riou C. Author Correction

Nature (2022) Mar;603(7901):488-492. doi: 0.1038/s41586-022-04460-3.

Impact of SARS-CoV-2 exposure history on the T cell and IgG response

Keeton R, Tincho MB, Suzuki A, Benede N, Ngomti A, Baguma R, Chauke MV, Mennen M, Skelem S, Adriaanse M, Grifoni A, Weiskopf D, Sette A, Bekker LG, Gray G, Ntusi NAB, Burgers WA, Riou C

Cell Rep Med. (2023) Jan 17;4(1):100898. doi: 10.1016/j.xcrm.2022.100898. PMID: 36584684; PMCID: PMC9771741.

Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV)

Khan K, Lustig G, Bernstein M, Archary D, Cele S, Karim F, Smith M, Ganga Y, Jule Z, Reedoy K, Miya Y, Mthabela N, Magula NP, Lessells R, De Oliveira T, Gosnell BI, Abdool Karim S, Garrett N, Hanekom W, Bekker L-G, Gray G, Blackburn JM, Moosa M-YS, Sigal A, Steyn A, Leslie A, Ramjit D, Wong E, Harling G, Kloverpris H, Marakalala J, Seeley J, Giandhari J, Dullabh K, Nyamande K, Herbst K, Naidoo K, Mazibuko M, Archary M, Moshabela M, Padayatchi N, Klein N, Mbatha N, Ngcobo N, Gumede N, Ngcobo N, Goulder P, Jeena P, Madansein R, Gupta RK, Harrichandparsad R, Singh S, Khoza T, Smit T, Ndung’u T, Patel V, Ndhlovu Z

Clinical Infectious Diseases (2022) 75 (1), pp. E857-E864. DOI: 10.1093/cid/ciab1008.

Effect of HIV viremia on neutralization capacity in infected unvaccinated participants. (A) Neutralization capacity as FRNT50 for Delta variant neutralization in SARS-CoV-2—infected unvaccinated HIV viremic (n=10) versus infected unvaccinated HIV-suppressed (n=24) participants. The dashed horizontal line represents most concentrated plasma used. (B) Frequency of nonresponders in panel A. Khan et al., 2022

SARS-CoV-2 Infection Is Associated with Uncontrolled HIV Viral Load in Non-Hospitalized HIV-Infected Patients from Gugulethu, South Africa

Lambarey H, Blumenthal MJ, Chetram A, Joyimbana W, Jennings L, Tincho MB, Burgers WA, Orrell C, Schäfer G

Viruses (2022) 14(6),1222. DOI: 10.3390/v14061222

Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials

Mena Lora AJ, Long JE, Huang Y, Baden LR, El Sahly HM, Follmann D, Goepfert P, Gray G, Grinsztejn B, Kotloff K, Rouphael N, Sobieszczyk M, Walsh SR, Andriesen J, Shah KA, Zhang Y, Gilbert P, Janes H, Gay CL, Falsey AR, Tripp RL, Gorman RL, Tong T, Marovich M, Neuzil K, Corey L, Kublin JG

JAMA Netw Open. (2023) Jan 3;6(1):e2251974. DOI: 10.1001/jamanetworkopen.2022.51974. PMID: 36689221

SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

Richardson SI, Manamela NP, Motsoeneng BM, Kaldine H, Ayres F, Makhado Z, Mennen M, Skelem S, Williams N, Sullivan NJ, Misasi J, Gray GG, Bekker L-G, Ueckermann V, Rossouw TM, Boswell MT, Ntusi NAB, Burgers WA, Moore PL

Cell Reports Medicine (2022). 3(2),100510. doi:10.1016/j.xcrm.2022.100510

Graphical Abstract -- Kitchin et al, 2022

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage

Scheepers C, Everatt J, Amoako DG, Tegally H, Wibmer CK, Mnguni A, Ismail A, Mahlangu B, Lambson BE, Martin DP, Wilkinson E, San JE, Giandhari J, Manamela N, Ntuli N, Kgagudi P, Cele S, Richardson SI, Pillay S, Mohale T, Ramphal U, Naidoo Y, Khumalo ZT, Kwatra G, Gray G, Bekker LG, Madhi SA, Baillie V, Van Voorhis WC, Treurnicht FK, Venter M, Mlisana K, Wolter N, Sigal A, Williamson C, Hsiao NY, Msomi N, Maponga T, Preiser W, Makatini Z, Lessells R, Moore PL, de Oliveira T, von Gottberg A, Bhiman JN.

Nat Commun. (2022) Apr 8;13(1):1976. doi: 10.1038/s41467-022-29579-9. PMID: 35396511

Sexual Health

Integration of gene expression, microbiome, and cytokine data Alisoltani et al., 2022

Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial

Balle C, Gupta PM, Tharp GK, Nelson SA, Konstantinus IN, Lennard K, Jaumdally SZ, Happel AU, Barnabas SL, Gill K, Bekker LG, Passmore JS, Jaspan HB, Bosinger SE.

Front Reprod Health. (2022) Mar 3;4:781687. doi: 10.3389/frph.2022.781687. PMID: 36303659

A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome

Chigorimbo-Murefu NTL, Potgieter M, Dzanibe S, Gabazana Z, Buri G, Chawla A, Nleya B, Olivier AJ, Harryparsad R, Calder B, Garnett S, Maziya L, Lewis DA, Jaspan H, Wilson D, Passmore JS, Mulder N, Blackburn J, Bekker LG, Gray CM.

Front Microbiol. (2022) Oct 17;13:928317. doi: 10.3389/fmicb.2022.928317. PMID: 36325020

Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression

Delgado-Diaz DJ, Jesaveluk B, Hayward JA, Tyssen D, Alisoltani A, Potgieter M, Bell L, Ross E, Iranzadeh A, Allali I, Dabee S, Barnabas S, Gamieldien H, Blackburn JM, Mulder N, Smith SB, Edwards VL, Burgener AD, Bekker LG, Ravel J, Passmore JS, Masson L, Hearps AC, Tachedjian G.

Microbiome (2022) Aug 31;10(1):141. doi: 10.1186/s40168-022-01337-5.PMID: 36045402

LC-MS-based proteomics of foreskin samples and data analysis methods used to assess the impact of aSTI on the foreskin proteome. Chigorimbo-Murefu et al., 2022

Intimate partner violence and contraception among adolescent girls and young women: A longitudinal analysis of the Girl Power-Malawi cohort

Grundy SJ, Maman S, Graybill L, Phanga T, Vansia D, Nthani T, Tang JH, Bekker LG, Pettifor A, Rosenberg NE

J Pediatr Adolesc Gynecol. (2022) Jul 6:S1083-3188(22)00246-7. doi:10.1016/j.jpag.2022.06.005. PMID: 35809851

Persistent, Asymptomatic Colonization with Candida is Associated with Elevated Frequencies of Highly Activated Cervical Th17-Like Cells and Related Cytokines in the Reproductive Tract of South African Adolescents

Happel AU, Gasper M, Balle C, Konstantinus I, Gamieldien H, Dabee S, Gill K, Bekker LG, Passmore JS, Jaspan HB

Microbiol. Spec. (2022) Mar 29:e0162621. doi: 10.1128/spectrum.01626-21. PMID: 35348351

Genome Sequences of Anelloviruses, a Genomovirus, Microviruses, Polyomaviruses, and an Unclassified Caudovirus Identified in Vaginal Secretions from South African Adolescents

Jimoh AO, Balle C, Brown B, Feng C, Havyarimana E, Konstantinus IN, Gill K, Bekker LG, Passmore JS, Jaspan HB, Varsani A, Happel AU.

Microbiol Resour Announc. (2023) Jan 24;12(1):e0114322. doi: 10.1128/mra.01143-22. Epub 2022 Dec 19.PMID: 36533922

Transkingdom Analysis of the Female Reproductive Tract Reveals Bacteriophages form Communities.

Madere FS, Sohn M, Winbush AK, Barr B, Grier A, Palumbo C, Java J, Meiring T, Williamson A-L, Bekker L-G, Adler DH, Monaco CL.

Viruses (2022), 14(2),430. doi: 10.3390/v14020430

Preliminary effectiveness and implementation outcomes of the IMARA-South Africa sexual health intervention on adolescent girls and young women: A pilot randomized trial

Merrill KG, Atujuna M, Emerson E, Blachman-Demner D, Bray BC, Bekker LG, Donenberg GR.

PLOS Global Public Health (2023) Feb 15;3(2):e0001092. doi:10.1371/journal.pgph.0001092. PMID: 36962830a

Women of Worth: the impact of a cash plus intervention to enhance attendance and reduce sexual health risks for young women in Cape Town, South Africa

Naledi T, Little F, Pike C, Edwards H, Robbertze D, Wagner C, London L, Bekker LG.

J Int AIDS Soc. (2022) Jun;25(6):e25938. doi: 10.1002/jia2.25938. PMID: 35700052

Women of Worth intervention schema. Naledi et al., 2022

Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice

Peters RPH, Garrett N, Chandiwana N, Kularatne R, Brink AJ, Cohen K, Gill K, Chidarikire T, Wattrus C, Nel JS, Moosa MYS, Bekker LG.

South Afr J HIV Med. (2022) Sep 27;23(1):1450. doi: 10.4102/sajhivmed.v23i1.1450. PMID: 36299557


Molecular Detection of Airborne Mycobacterium tuberculosis in South African High Schools

Bunyasi EW, Middelkoop K, Koch A, Hoosen Z, Mulenga H, Luabeya AKK, Shenje J, Mendelsohn SC, Tameris M, Scriba TJ, Warner DF, Wood R, Andrews JR, Hatherill M. Molecular

American Journal of Respiratory and Critical Care Medicine (2022). 205(3), pp. 350-356. doi: 10.1164/rccm.202102-0405OC.

Non-volatile organic compounds in exhaled breath particles correspond to active tuberculosis

Chen D, Bryden NA, Bryden WA, McLoughlin M, Smith D, Devin AP, Caton ER, Haddaway CR, Tameris M, Scriba TJ, Hatherill M, Gessner S, Warner DF, Wood R.

Scientific Reports (2022). 12 (1), 7919. doi:10.21203/

Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study

Denti P, Wasmann RE, van Rie A, Winckler J, Bekker A, Rabie H, Hesseling AC, van der Laan LE, Gonzalez-Martinez C, Zar HJ, Davies G, Wiesner L, Svensson EM, McIlleron HM.

Clin Infect Dis. (2022) Aug 24;75(1):141-151. doi: 10.1093/cid/ciab908. PMID: 34665866; PMCID: PMC9402673.

Importance of ventilation and occupancy to Mycobacterium tuberculosis transmission rates in congregate settings

Deol AK, Shaikh N, Middelkoop K, Mohlamonyane M, White RG, McCreesh N.

BMC Public Health (2022), 22 (1), 1772. doi:10.1186/s12889-022-14133-5

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rücker SCM, Heidebrecht C, Wilson D, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G.

The Lancet HIV (2022) Apr;9(4):e233-e241. doi: 10.1016/S2352-3018(22)00002-9.

Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: A systematic review and individual participant data meta-analysis

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Broger T, Denkinger CM, Rangaka MX, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rücker SCM, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G.

Journal of Infection (2022) Jul;85(1):40-48. doi:10.1016/j.jinf.2022.05.010.

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G.

The Lancet Infectious Diseases (2022) 22(4), pp. 507-518. doi:10.1016/S1473-3099(21)00387-X

The impact of a change in infant BCG vaccination policy on adolescent TB incidence rates: A South African population-level cohort study

Fack C, Wood R, Hatherill M, Cobelens F, Hermans S.

Vaccine (2022) 40(2), pp. 364-369. doi:10.1016/j.vaccine.2021.11.043.

Improving Estimates of Social Contact Patterns for Airborne Transmission of Respiratory Pathogens

McCreesh N, Mohlamonyane M, Edwards A, Olivier S, Dikgale K, Dayi N, Gareta D, Wood R, Grant AD, White RG, Middelkoop K.

Emerg Infect Dis. (2022), Oct;28(10):2016-2026. doi: 10.3201/eid2810.21256

Prevalence and Determinants of Vitamin D Deficiency in 1825 Cape Town Primary Schoolchildren: A Cross-Sectional Study.

Middelkoop K, Walker N, Stewart J, Delport C, Jolliffe DA, Nuttall J, Coussens AK, Naude CE, Tang JCY, Fraser WD, Wilkinson RJ, Bekker LG, Martineau AR.

Nutrients (2022) Mar 16;14(6):1263. doi: 10.3390/nu14061263. PMID: 35334921

Neighbourhood risk factors of recurrent tuberculosis in Cape Town: a cohort study using geocoded notification data.

Molemans M, Van Leth F, Mckelly DH, Wood R, Hermans S.

Journal of Epidemiology and Community Health (2022) 77 (1), pp. 56-62. doi:10.1136/jech-2022-219622

Estimating Tuberculosis Transmission Risks in a Primary Care Clinic in South Africa: Modeling of Environmental and Clinical Data

Zürcher K, Riou J, Morrow C, Ballif M, Koch A, Bertschinger S, Warner DF, Middelkoop K, Wood R, Egger M, Fenner L.

Journal of Infectious Diseases (2022) 225(9), pp. 1642-1652. doi:10.1093/infdis/jiab534

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